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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MCM2
All Species:
24.85
Human Site:
T39
Identified Species:
36.44
UniProt:
P49736
Number Species:
15
Phosphosite Substitution
Charge Score:
0.13
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P49736
NP_004517.2
904
101896
T39
S
R
R
T
D
A
L
T
S
S
P
G
R
D
L
Chimpanzee
Pan troglodytes
XP_001136482
895
100908
S44
L
P
P
F
E
D
E
S
E
G
L
L
G
T
E
Rhesus Macaque
Macaca mulatta
XP_001099580
870
97929
T39
S
R
R
T
D
A
L
T
S
S
P
G
R
D
L
Dog
Lupus familis
XP_541736
1001
113024
T136
S
R
R
M
D
A
L
T
S
S
P
G
R
D
L
Cat
Felis silvestris
Mouse
Mus musculus
P97310
904
102059
T39
S
R
R
A
D
A
L
T
S
S
P
G
R
D
L
Rat
Rattus norvegicus
NP_001101343
905
102125
T40
S
R
R
A
D
A
L
T
S
S
P
G
R
D
L
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001518428
911
102482
T45
R
G
G
I
D
A
L
T
S
S
P
G
R
D
L
Chicken
Gallus gallus
NP_001006139
888
100332
S39
L
P
P
F
E
D
E
S
E
G
L
L
G
T
G
Frog
Xenopus laevis
P55861
886
100243
E39
P
P
F
E
D
E
S
E
G
M
F
G
D
G
V
Zebra Danio
Brachydanio rerio
NP_775364
880
98286
E39
P
P
F
E
D
E
S
E
G
L
L
G
D
T
L
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P49735
887
100396
E40
E
P
F
E
N
E
D
E
I
L
G
D
Q
T
V
Honey Bee
Apis mellifera
XP_395109
1005
114136
T146
D
R
H
T
E
A
M
T
S
P
A
P
E
I
D
Nematode Worm
Caenorhab. elegans
Q21902
759
84917
Sea Urchin
Strong. purpuratus
XP_001177558
884
100012
S40
L
P
P
F
E
D
E
S
E
L
Q
P
G
G
V
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Q43704
768
85163
R13
E
A
M
A
A
H
K
R
A
F
L
D
F
L
D
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P29469
868
98761
I46
P
I
G
S
P
D
M
I
N
P
E
G
D
D
N
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99
95.8
87.4
N.A.
95.5
96
N.A.
93.1
88.2
86.7
80.1
N.A.
63.9
58.4
26.7
73.4
Protein Similarity:
100
99
96.1
89.1
N.A.
97.7
98.3
N.A.
95.7
93.8
93
87.6
N.A.
79.3
73.5
43.2
86.5
P-Site Identity:
100
0
100
93.3
N.A.
93.3
93.3
N.A.
73.3
0
13.3
20
N.A.
0
33.3
0
0
P-Site Similarity:
100
13.3
100
93.3
N.A.
93.3
93.3
N.A.
73.3
13.3
20
20
N.A.
20
46.6
0
20
Percent
Protein Identity:
N.A.
30.3
N.A.
N.A.
41.9
N.A.
Protein Similarity:
N.A.
48.8
N.A.
N.A.
58.9
N.A.
P-Site Identity:
N.A.
0
N.A.
N.A.
13.3
N.A.
P-Site Similarity:
N.A.
6.6
N.A.
N.A.
33.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
7
0
19
7
44
0
0
7
0
7
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
7
0
0
0
50
25
7
0
0
0
0
13
19
44
13
% D
% Glu:
13
0
0
19
25
19
19
19
19
0
7
0
7
0
7
% E
% Phe:
0
0
19
19
0
0
0
0
0
7
7
0
7
0
0
% F
% Gly:
0
7
13
0
0
0
0
0
13
13
7
57
19
13
7
% G
% His:
0
0
7
0
0
7
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
7
0
7
0
0
0
7
7
0
0
0
0
7
0
% I
% Lys:
0
0
0
0
0
0
7
0
0
0
0
0
0
0
0
% K
% Leu:
19
0
0
0
0
0
38
0
0
19
25
13
0
7
44
% L
% Met:
0
0
7
7
0
0
13
0
0
7
0
0
0
0
0
% M
% Asn:
0
0
0
0
7
0
0
0
7
0
0
0
0
0
7
% N
% Pro:
19
38
19
0
7
0
0
0
0
13
38
13
0
0
0
% P
% Gln:
0
0
0
0
0
0
0
0
0
0
7
0
7
0
0
% Q
% Arg:
7
38
32
0
0
0
0
7
0
0
0
0
38
0
0
% R
% Ser:
32
0
0
7
0
0
13
19
44
38
0
0
0
0
0
% S
% Thr:
0
0
0
19
0
0
0
44
0
0
0
0
0
25
0
% T
% Val:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
19
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _